NI cryptographic checksum mismatch error: 12599

In testing of Oracle Enterprise Manager 11g R1 Grid Control we noticed frequent ORA-12599 errors in the alert logs of the monitored databases including the repository database. Upon further investigation we found that the ORA-12599 error message, such as the one below, was generated every time a connection was made to the target database as SYSDBA through Oracle Enterprise Manager 11g R1 Grid Control.
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